His most productive season came in 1962 with Minnesota and the Angels, when he compiled career-highs in victories (11), strikeouts (102), shutouts (2) and innings pitched (205+1⁄3).

On September 2, 1960, Lee surrendered a home run to Ted Williams in the first game of a doubleheader between the Senators and Boston Red Sox.

[1] 21 years before, in his rookie season, Williams hit a home run off Don's father Thornton Lee, then with the Chicago White Sox, on September 17, 1939.

With this feat, Williams became the only player in major league history to hit home runs against a father and son.

[2] In a nine-season career, Lee posted a 40–44 record with 467 strikeouts, a 3.61 ERA, 11 saves, and 828+1⁄3 innings in 244 games played (97 as a starter).