His handmade quality and non-traditional modes of art making are displayed in his drawings, paintings, sculptures and installations that highlight his inventive tools and skills.

Porcella often references art historical movements, makes fun of absurd consumer culture, the human condition and alien conspiracy theories that allow the subjective and strange to penetrate humorous representations of a wildly imaginative reality.

Don Porcella co-wrote the song "Vacuum",[15] a collaboration with Iranian artist Salome MC during the Swatch Art Peace Residency in Shanghai.

He has participated in numerous solo exhibitions, his shows include: Don Porcella: Cave Dwellers (2011) Newhouse Center for Contemporary Art, Staten Island;  Fiber in the 21st Century (2011) at the Lehman Art Gallery, Bronx, New York; Don Porcella: Top Flight Projects (2014) Swatch Exhibition Shanghai; Creatures in Wonderland[17] (2016), Hermès Maison Shanghai, China; The Games We Play (2018)  Hermès, New York.

His works have been exhibited internationally at galleries and museums around the world including the United States, China, Greece, Germany, France, Denmark, Colombia and Mexico.