The novel, set in Salvador, Bahia, opens with the sudden death of Dona Flor's husband, Vadinho, who collapses in the midst of Carnival celebrations.

He is dancing a samba in the streets when his heart gives out, a surprise to all as Vadinho had spent his entire life gambling, partying and drinking with no hint of problems.

After a period of mourning, Dona Flor attracts another admirer, a local pharmacist, Teodoro.

While her new husband lacks the passionate sensuality of Vadinho, he compensates by providing a life free of worry.

His activities create commotion everywhere, from Dona Flor's marriage bed to the local nightspots.