O'Toole urged others to follow the example of Dungannon and Donaghmore so that Tyrone would "soon be ablaze with enthusiasm for the revival of our national games and pastimes".

On 18 December 1927, led by team captain Johnny McCullough, Donaghmore GAA won the 1927 Tyrone Senior Championship Final, beating Ardboe Pearses 1–7 to 0–9 in Dungannon, the year that the event was awarded by the O'Neill Cup for the first time.

Father Eamon Devlin was appointed as curate for the Donaghmore area in October 1941, where he stayed for most of his clerical life until 1969.

Under Devlin's guidance, a meeting was held on 26 January 1944, which resulted in the renaming of the club to its current name of Donaghmore St Patrick's.

In 1978, Denise McMullan won an All-Ireland title in Scór na nÓg in the recitation section.

However, the next few years saw Donaghmore struggle to keep senior status, being relegated in 1985, winners of the 1986 Tyrone ACL Division 2 title, and runners up in the 1986 Intermediate Championship Final, losing after a replay.

Gary and Richard Hetherington took over as managers hoping to bring the club back to Senior football, which they did, with Donaghmore also winning the Minor grade two league title, and their first Reserve Intermediate Championship.