He then moved to the United Kingdom where he was at St Thomas's Hospital Medical School, and served as senior lecturer at University of London between 1976 and 1982.

After that, at Columbia University, he undertook internship at Montefiore Hospital and Medical Center in New York, and served as an Administrative Intern.

He conducted a 10-year program of research in Lambeth in London on the care of persons with physical disabilities culminating in a series of papers and a book.

[13] While investigating the community functioning of individuals suffering from Schizophrenia, his research highlighted that although behavioral assessment and clinician ratings can be efficient for the clinical trials, there is still a need for the development of adequate valid and reliable instruments.

[14] Since, health-related quality of life (HRQL) measurement is considered vital for guiding patient care and policy choices, as recognized by clinicians and decision-makers alike.

It has also been explained that for the (HRQL) measures to be easily comprehended by the clinicians, and policymakers alike so as they can analyze score differences, and achieve meaningful outputs.

[15] It has also been demonstrated with his research works how the assessment of QOL regarding health in the clinical practice can lead to myriad benefits including, disease prevention, reduction in pain or discomfort symptoms, avoidance of complications, with a goal to promote a prolonged life.

[16] Patrick was a Special Government Employee for 10 years working on and culminating in the publication on the Food and Drug Administration Guidance on the Use of Patient Reported Outcomes in Medical Product Evaluation and labeling.

A conference reported that the before employing the treatment interventions, assessment must be carried out focused on the symptom, pain, depression, and fatigue management in cancer patients.

In addition to that, the key factors which may influence the cancer-related distress, and symptom management including limited knowledge, and effectiveness of the treatment interventions have been addressed by his research as well.

The inattention to the non-fatal diseases in the health care services have been identified, specifically in young adults and primarily corresponds to their prevalence.

[23] Based on a self-report questionnaire results by adults with chronic conditions, improved functional status with the presence of fewer depressive symptoms, leads to better quality of life.

[24] Patrick is most known for his work on outcomes research which covers a broad range of aspects, particularly focused on vulnerable populations, chronic illness, as well as end of life care.

[30] Ray Moynihan reviewed Richard Deyo and Patrick's book Hope or Hype: The Obsession with Medical Advances and the High Cost of False Promises and wrote that it is, "Packed full of powerful examples, and destined to serve as a reference book for future generations of students...", but called the appraisal of commercially driven medicine unnecessary, and said that that focus needs to shifted upon the how to solve the dilemma of excess of profitable medicines rather than just its diagnosis.