Quality of Life Research is a peer-reviewed academic journal covering research into quality of life from a medical and public health perspective.

It was established in 1992 and is published ten times per year by Springer Science+Business Media.

It is the official journal of the International Society of Quality of Life Research.

The editors-in-chief are Jan Böhnke (University of Dundee) and Claudia Rutherford (University of Sydney).

According to the Journal Citation Reports, the journal has a 2017 impact factor of 2.392.