Donald McKenzie (16 June 1783 – 20 January 1851) was a Scottish-Canadian explorer, fur trader and Governor of the Red River Colony from 1821 to 1834.

McKenzie spent two years exploring and trading for the Pacific Fur Company in the Willamette Valley, along the Columbia River, in eastern Washington and in northern and central Idaho.

When PFC sold its assets and stations to the North West Company in 1813, McKenzie was appointed to carry all important papers back east, which he did in 1814.

He left the Pacific Northwest and moved to Fort Garry for a decade, serving as governor for most of present-day Manitoba, Saskatchewan, and Alberta, Canada.

He gave advice on where the international boundary should be established for the Oregon Territory, and may have planted the seeds that led to the purchase of Alaska from Russia.