Moffett was born in San Antonio, Texas, where he studied art and biology at Trinity University, earning a BA.
His influence by classical painters such as Goya and Manet is manifest in his blending of the subtle with the outlandish and structural experimentation with social critique.
While his artwork provides contemporary views on important topics of our modern-day lives, it is also a meditation on the timeless and universal issues of love, loss, alienation, and death.
[8][9] Moffett is a founding member of Gran Fury, the artistic arm of the AIDS activist group ACT UP.
[12] Moffett is represented by Marianne Boesky Gallery in New York,[13] and Anthony Meier Fine Arts in San Francisco.