Dondup Tseten Dorje (Tibetan: དོན་གྲུབ་ཚེ་བརྟན་རྡོ་རྗེ, Wylie: don grub tshe brtan rdo rje; d. 1620) was the penultimate prince of the Rinpungpa dynasty which held power in Tsang (West Central Tibet) between 1435 and 1565.
The details of succession are obscure, however, since his brothers Ngawang Jigme Drakpa and Rinchen Wanggyal are known to have captured the important stronghold Samdrubtse in 1547 from unspecified enemies, and to have obtained a ruling position.
He also established a preceptor-patron relationship with the lama Kunkhyen Pema Karpo (1527–92) of the Drukpa Kagyu sect, who visited Dondup Tseten Dorje in his castle in 1549.
Dondup Tseten Dorje or his brother Ngawang Jigme Drakpa suffered a notable defeat in 1555 when the Rinpungpa vainly attacked the Mangyül Gungthang kingdom in western Tibet.
Dondup Tseten Dorje stood in a family relation with the victorious Tsangpa dynasty since he is referred as the "uncle" of king Karma Phuntsok Namgyal (r. 1611–1620).