Pescow attended Sheepshead Bay High School in Brooklyn and studied at the American Academy of Dramatic Arts.

[2] Also in 1977, Pescow joined the cast of the ABC soap opera One Life to Live, portraying Celena Arquette.

In 1978, Pescow portrayed one of Judy Garland's older sisters in the television biographical film Rainbow, directed by Jackie Cooper.

In 1982, Pescow was cast in the role of Dr. Lynn Carson, the first lesbian on a daytime serial, on the soap opera All My Children, which she played until 1983.

She made guest appearances on the shows Clueless, NYPD Blue, Pauly and Ivory Tower, and in the 1998 television film Dead Husbands.

After taking several years off following Even Stevens, Pescow appeared in the film One Sung Hero alongside Nicole Sullivan.