Becoming a tenured professor of pharmacology, she was well known for her research and classes keeping on the edge of new biochemical visualization technologies into the 1980s, along with her efforts to promote the advancement of women in science at the university.

She would continue in the following decades to show how alcohol molecules impact cellular membranes and induce resistance and dependency after long term exposure, along with the genetic markers making an individual higher risk for developing such an addiction.

Afterwards, she went to Harvard Medical School as a part of its first ever women-allowed class and studied with doctor and pharmacologist Avram Goldstein, whom she married.

Her work would eventually have her become a full faculty member, which allowed her to begin independent research on the pharmacology of alcohol.

She also became a member of the Katharine McCormick Society, from which she was able to obtain funds for Stanford to create the McCormack Faculty and Postdoctoral Fellows Awards to gift scholarships to prospective women applicants.

[2] From a philosophical perspective, her work on drug dependence showing that addiction was a cellular response to toxins in order to reduce the harm said substances cause in the body, along with withdrawal being a physiological response to altered cells no longer having the substance they had altered to work with, ran counter to common sentiment of the time period in the 1960s and 1970s.

[5] Then, in multiple studies throughout the early 1970s, she tested the effects of ethanol on mice and increasing levels of alcohol withdrawal.