In 1929, she and Dorthea Wallace Ward bought a 25-acre farm near Williamsburg, known as Village Hill Nursery.

[3][4] Brigham sold off the farm's livestock when Ward left to marry in 1939, but expanded the mail order business in herbs, adding a grape arbor, a greenhouse, and a pond.

[1] Brigham retired around 1957, maintaining a mountaintop garden in Cashiers, North Carolina and spending the winter months in Mount Dora, Florida.

[10] She lectured to community groups,[11][12][13] and led Audubon field trips to Corkscrew Swamp and Sanibel Island into the 1970s.

[15] Brigham traveled in her retirement, studying plant and animal life in Fiji, Australia, and Greece in her seventies.