She has previously served as president of the companies Frog Design Inc. and Quirky and was the marketing director for Power Computing, manufacturer of "Mac Clones" based in Round Rock, Texas.

In 1997, Lorenzo was the marketing director at Power when Steve Jobs, the then-interim CEO for Apple Inc, terminated the Mac-cloning enterprise.

[2] The user interface firm she hired to launch the company's online store was acquired by Frog Design Inc.

[4] She eventually became the president of the company's digital media group, which created commercial websites and graphical user interfaces.

[4][9] As president, Lorenzo was involved in "driving strategy, overseeing worldwide operations and delivery, and leading the design firm to record growth".

[7][15] Lorenzo co-founded Vidlet, a mobile video insights company, alongside former Frog employees Patricia Roller and Nate Pagel, as well as Kieran Farr, the founder of Vidcaster.

[4][28] She has contributed to ABC News, Bloomberg Radio and Fortune,[29] and has been quoted by Fast Company and The New York Times, amongst other publications.

[33][34] She was also invited to speak at a panel discussion on the sharing economy, hosted by Spencer Ante, the co-founder of WhoWeUse, in New York City.

[38][39] As one of the first female leaders in the modern business of product design and innovation, she has been described as a "strategic thinker" with a passion for "helping creative people succeed".