[2][3] She was a co-founder of Oyate, an advocacy and education organization which reviews children's literature to ensure it treats Native Americans with "historical accuracy, cultural appropriateness and without anti-Indian bias and stereotypes".

Her last published work, A Broken Flute: The Native Experience in Books for Children, dealt with issues of cultural appropriation.

It included a chapter on deconstructing the myths perpetuated about the first Thanksgiving, helping educators create more culturally appropriate activities for the holiday.

When she received the ALA Equity Award in 2001, the ceremony was being held at the Marriott Hotel in San Francisco, a hotel that was in a labor dispute with its workers.

Seale joined that picket line rather than go inside to accept her award.