She married on 2 February 1556 in Gera Henry V of Plauen, Burgrave of Meissen (1533–1568).
The wedding of the financially ailing burgrave was celebrated with splendor: 1,500 guests were there, with 970 horses, 250 of them noblemen.
The wedding celebration plunged Henry into considerable debt, which caused him to conclude the treaty of Annaberg with Elector August of Saxony a few weeks later, on 13 March.
[1] From her marriage, Dorothy Catherine had four sons, all named Henry.
Dorothy Catherine died in 1604 and was buried next to her husband in the Mountain Church in Schleiz.