Her film career began in 1923 with the role of Eleanor Harmon in The Call of the Canyon, directed by Victor Fleming.

[citation needed] Seastrom barely avoided a potentially disfiguring accident during the filming of We Moderns (1925).

Seastrom escaped injury when assistant director James Dunne grabbed a tablecloth from a prop table and covered the actress's head.

[citation needed] In 1926, Seastrom missed six months from acting while she had to rest in a sanitarium and "build up a physique weakened by work and worry".

(The widower Corby wed a young script girl turned actress named Ellen Hansen in 1934; they divorced in 1944.)