Mouscron is divided into 7 districts: the downtown (le centre), the train station (la gare), Mont-à-Leux, Tuquet, Risquons-Tout, Nouveau-Monde and Coquinie.

The textile industry started in Mouscron in the 1760s thanks to the imposition by Lille of a ban on the fabrication of molletons, a mixture of flax and wool, in Roubaix and Tourcoing.

On March 29, 1848, the Belgian army intervened near Mouscron against a troop of French republican sympathizers who were ready to invade Belgium, in what was known as the Risquons-Tout incident.

By the end of the century, several cotton mills and carpet plants were built, leading the village to expand into a much larger urban area, especially after the close of World War I.

The studio of Marcel De Keukeleire and Jean Van Loo produced famous European artists like Chocolat's (Brasilia Carnaval), Patrick Hernandez (Born to Be Alive), Amadeo (Moving Like A Superstar), J.J. Lionel (Chicken dance) and the Crazy Horse band, which was partly made up of people from Mouscron.

Other artists of the 1960s to have performed in the club include: The Animals, The Small Faces, The Kinks, The Yardbirds, Gene Vincent, The Moody Blues.

[citation needed] In 1978, their Song “Top rank suite” alludes to the city's name with the sentence: “They played a good game of football in Mucron”.

Eventually, the beginning of the song “Les Bourgeois” of Jacques Brel, anecdotally mentions the name of “Adrienne du Mont-à-Leux”, who was the owner of a café in the city.