The journey starts on the city streets and progresses through an outer-space dojo, Asian countryside, a genetics lab, and a graveyard before concluding at Skullmageddon's palace.

The player can collect life-replenishing sodas, money to buy items from shops, and special mixtapes that can be equipped from a pause menu.

Each tape's maximum capacity can be increased further by visiting a "Tapesmith" and paying him Mythril, which is obtained from defeated bosses.

In a two-player game, both Billy and Jimmy can utilize a special "high-five" technique to split and share their life meters to an equal amount, "psych" the other one out to harm them or make them fall over, or to instantly trigger a Gleam effect.

[7] Skullmaggedon along with the Double Dragon Neon incarnations of Billy, Jimmy and Marion would later cameo as shopkeepers for WayForward's River City Girls (a spin-off game based on the Kunio-kun property by Technos Japan).