[citation needed] On 15 February 2012, Douglas Santos made his first team debut, in a 2–0 home win over Central.

[7] On 12 July 2013, Douglas Santos signed a five-year deal with La Liga side Granada CF, for an undisclosed fee.

[citation needed] On 20 July 2015, Galo signed Douglas Santos permanently for €3 million on a four-year contract.

[citation needed] On 4 July 2019, Douglas Santos joined Russian Premier League side FC Zenit Saint Petersburg, signing a five-year contract.

[18] On 13 August 2015, Douglas Santos returned to the senior team, for friendlies against Costa Rica and the United States.