His trophy cabinet with PSG includes a record nine Ligue 1 titles and thirteen domestic cups, and he ranks top for all-time appearances for the club.

[15] After the conclusion of the state championship, Marquinhos made his Campeonato Brasileiro Série A debut on 20 May 2012, playing the full 90 minutes in a 0–1 loss to Fluminense at the Paulo Machado de Carvalho Stadium; both teams were resting players in the first game of the season due to concentration on the Copa Libertadores.

[20] Marquinhos made his debut on 16 September in a 2–3 loss against Bologna at the Stadio Olimpico, sent on by manager Zdeněk Zeman to replace Iván Piris for the match's final 15 minutes.

[21] By October, Zeman decided to partner Marquinhos for his speed alongside former Corinthians teammate and fellow Brazilian Leandro Castán in central defence, demoting former starter Nicolás Burdisso to the substitutes' bench.

[22] He given a straight red card in a 4–2 victory over Milan on 22 December when he was judged to have denied Stephan El Shaarawy a clear goalscoring opportunity.

[7] French news channel BFM TV described the transfer as the fifth most expensive of all time for a defender, after those of Rio Ferdinand, Thiago Silva, Lilian Thuram and Dani Alves.

[28][29] On his official debut for the club on 17 September, Marquinhos scored his first professional goal to confirm a 4–1 win against Olympiacos at the Karaiskakis Stadium in the group stage of the 2013–14 UEFA Champions League.

[33] Marquinhos scored the last goal of PSG's 6–1 aggregate win over Bayer Leverkusen in the last 16 of the Champions League on 12 March 2014,[34] and was an unused substitute as they won the Coupe de la Ligue final against Lyon on 19 April.

[36] Marquinhos began the 2014–15 season on 2 August in the Trophée des Champions, playing the whole 90 minutes as PSG won 2–0 against Guingamp at the Workers Stadium in Beijing.

"[39] As the right-back in an all-Brazilian defence (alongside Maxwell, Thiago Silva and David Luiz), Marquinhos featured in PSG's 3–2 win at Marseille in Le Classique, scoring the equaliser.

[40] Six days later, he started in the 4–0 victory over Bastia in the 2015 Coupe de la Ligue, his 34th consecutive game without a defeat for the club, surpassing a record set by George Weah.

[41] On 16 May, PSG won their third consecutive league title with a 2–1 victory at Montpellier, with Marquinhos playing the final 12 minutes in place of Yohan Cabaye.

[42] Two weeks later, he was an unused substitute as the team finished a perfect domestic season with victory in the Coupe de France final against Auxerre.

[43] PSG began the 2015–16 season with a 2–0 victory over Lyon in the 2015 Trophée des Champions, with Marquinhos an unused substitute as Serge Aurier played at right back.

[50] He was tipped by ESPN journalist Jonathan Johnson to play more frequently over the season, as new manager Unai Emery sold David Luiz back to Chelsea.

[55] Marquinhos began the 2017–18 season on 29 July, starting as PSG won 2–1 in the 2017 Trophée des Champions at the Grand Stade de Tanger in Morocco.

[69] Marquinhos played every minute of Brazil's campaign at the 2011 South American Under-17 Football Championship, as they won and qualified for that year's World Cup in that category.

[71] However, later that month, he received his first call-up for Brazil when Luiz Felipe Scolari named his squad for friendly matches against Honduras and Chile to be played that November.

[78] In 2016, Marquinhos was named in the Brazilian squad for the Copa América Centenario in the United States, an "experimental" selection lacking his Paris Saint-Germain defensive partners Thiago Silva and David Luiz.

[80] Later that year, he was included in the squad for the team's hosting of the Olympic tournament,[81] and in the semi-final against Honduras in Rio de Janeiro, he scored in an eventual 6–0 win.

[89] On 9 October 2020, Marquinhos scored his first competitive goal for Brazil, heading the opener of a 5–0 win over Bolivia at Corinthians' ground, in 2022 FIFA World Cup qualification.

[20] In March 2015, Marquinhos told FourFourTwo that he compensated for his average height for a defender by honing his strength and timing, attributes he learnt from PSG assistant manager Claude Makélélé.

They wrote, "He has the temperament to remain undaunted, the talent to succeed, and could benefit from playing alongside his club team-mate, Thiago Silva, with whom he enjoys a solid understanding at wealthy Paris Saint-Germain.

[107] Their daughter was born on 1 November 2017, with Cabrino having gone early into labour while watching Marquinhos playing a Champions League match against Anderlecht at the Parc des Princes.