An equestrian sculpture by Elisabeth Frink stands on the junction of Dover Street and Piccadilly, opposite the Ritz Hotel.

Anne Lister (1791–1840), a notable Victorian landowner and diarist, liked to stay at Hawkins, located at 26 Dover Street.

Other guests have included Napoleon III, Theodore Roosevelt (at the time of his marriage), Rudyard Kipling and Agatha Christie (her book At Bertram's Hotel is based on Brown's).

Oliver Wendell Holmes in Our Hundred Days in Europe records staying at Mackellar's Hotel, 17 Dover Street, where "we found ourselves comfortably lodged and well cared for during the whole time we were in London".

In the 1920s many notable photographers were based in Dover Street including Paul Tanqueray, Hugh Cecil and Alexander Bassano.

The original Leslie Green-designed building was located in Dover Street, but, following refurbishment in the 1930s to install escalators, the entrance was moved to Piccadilly and the station was renamed.