[2] After marrying the daughter of the wealthy Solomon Bornstein of Wieliczka, he settled as a banker and rabbi in Kraków.
In 1832 he would become Kraków's Chief Rabbi, though he was not recognized by the entire community, a considerable part of which adhered to his opponent, Saul Landau.
[2] In 1856 Meisels became rabbi of Warsaw (in the Russian-ruled sector of Poland), where he soon won the respect and confidence of the entire population.
[2] He accompanied the Archbishop of Warsaw at the funeral of victims of the first disturbances and marched with Father Wyszyński at the head of a delegation to city hall.
After his funeral, which turned into a large Polish-Jewish anti-Russian demonstration, the Russian government forbade obituaries of him to be printed.
[4] Meisels was the author of novellæ on the Sefer ha-Miẓwot of Maimonides, which appeared together with the text as Ḥiddushe MaHaRDaM.