It was founded in 1945 and named after British civil servant Sir Hugh Dow, Governor of Sindh.

[2] In 2003, it became a constituent college of the newly formed Dow University of Health Sciences.

The Government of Sindh under the lead of then Health minister Dr. Hemandas Wadhwani, arranged this transfer.

[4] The 20 member teaching faculty was led by Dr Kewalram Tarasing Ramchandani as the Principal.

[7] Dow Medical college is a large provider of physicians to Pakistan and also to the United States.