[12] At the time of establishment of Pakistan as a sovereign state in 1947, the means for higher education and research were negligible and diminished in the country.

In a short span of 40 years, the university has risen to acquire a high status in the field of education in Pakistan as well as in the region.

On November 27, 2023, the Bohra community leader Dr Syedna Mufaddal Saifuddin inaugurated a new state-of-the-art facility for law students on the Karachi University (KU) campus.

[23] The new School of Law building, spread over 45,000 square feet, features an Islamic ethos of positive change through education.

With its large capacity, the building will allow a greater number of graduate and postgraduate students to pursue multiple law programs.

Established and constructed in 1952, the Dr. Mahmud Hussain Library is an imposing five story and basement structure firmly placed in the center of campus activities.

[33] Mahmud Hussain served as the university's Vice-Chancellor from 1971 to 1975 and the library was named in recognition of his contribution to the teaching of social sciences in Pakistan.

He also actively worked to improve the status and pay scales of the library staff to make them at par with the university's other faculty members.

[5] A visit has been made by English Higher Education Leader Chris Husbands to begin collaborative awarding.

On 26 April 2022, four people including three Chinese nationals, were killed and four others were injured in a suicide attack outside the Confucius Institute located within the University of Karachi.

[41] A female suicide bomber was spotted in the attack footage, who was sent by a militant separatist group BLA Baloch Liberation Army operating from Balochistan.