At the age of 17 he moved to Nashville, Tennessee to work in a drug store owned by his older brothers Gilman and George; later he and Gilman opened a branch store in Memphis.
[2] He married a woman named Lucinda Brown, but she died 6 months later, and Bramble loaded up a wagon full of goods and moved to the frontier at Yankton.
In January 1866 he remarried, this time to Virginia Van Der Hule, with whom he had two children, Harry Jesse and Frank Litchfield Bramble (1871-1966).
At Yankton, Bramble established a general store, bringing goods by ox cart from Sioux City.
In 1884 he was appointed receiver at the government land office in Watertown, South Dakota and moved his family there.