Starring alongside Pratt are Kristen Wilson as Lisa Dolittle and Norm Macdonald as the voice of Lucky the Dog.

17 years later, it was revealed in a 2023 interview that the reason they did not return was because Murphy was too uncomfortable playing the father of a grown adult daughter.

Like her sister Charisse, she inherits their father John's capacity for communicating with animals (she is a part-time veterinary assistant), her life has changed drastically on all fronts.

With John away on business, Maya's mother Lisa sends her and her dog Lucky to a dude ranch named "Durango", so she can find herself.

[3] Scott Weinberg of DVD Talk gave the film 1.5 out of 5, writing, "Cheap-looking, atrociously written, and delivered with all the energy of a breach-birth bovine, Dr. Dolittle 3 is all kinds of terrible".