The game follows Dr. Muto, a maniacal and genius mad scientist whose latest experiment has accidentally destroyed his own home planet.

Dr. Muto uses his invention, the Splizz Gun, to mutate and morph into other organisms to complete his tasks.

Dr. Muto, a mad scientist, built a machine that would provide free, renewable energy for his home planet of Midway.

However, the machine was sabotaged by Muto's rival, Professor Burnital, causing it to malfunction and destroy the planet.

Hilary Goldstein of IGN gave the game an 8.5 out of 10, stating that Muto has "sly humor, difficult challenges, and some fantastic gameplay elements.