The series, starring dermatologist and Internet celebrity Dr. Sandra Lee, follows her as she treats patients with unusual cases of facial and skin disorders at her clinic Skin Physicians & Surgeons in the Inland Empire city of Upland, California.

[4] Another hour-long special was aired on December 13, 2018, before the second season began on January 3, 2019 with its episodes moved to 9 p.m. Eastern Time on Thursdays.

A spin-off series titled Dr. Pimple Popper: Before the Pop premiered on September 3, 2020.

[6] On August 5, 2020, it was announced that a spin-off series titled Dr. Pimple Popper: Before the Pop would premiere on September 3, 2020.

[99] Kristen Baldwin of Entertainment Weekly gave the pilot episode a "B" rating, commenting that "Pimple Popper delivers that blast of feel-good warmth you want from a makeover show, as the patients offer tearful post-procedural testimonials about how Dr. Lee changed their life for the better.