[3] The show premiered on October 1, 2007; it aired Monday nights at 11:05 pm Eastern/10:05 pm Central, immediately after WWE Raw, on the USA Network.

In every episode, Dr. Steve-O helps three different men, and makes them complete three challenges to overcome their fears.

The show begins with Dr. Steve-O riding in a customized ambulance along with his driver (Reggie) and nurse (Trishelle), showing the viewers videos sent in by men who want to overcome their fear.

If someone decides that a challenge is too embarrassing for them, they can simply walk away and risk being called a "wuss".

People who complete the process are awarded clean bills of health by Steve-O, who usually staples them onto the recipients.