Set on a concrete foundation on a hill overlooking Walthill, the one-and-one-half-story hospital was built in the American Craftsman style of architecture.

A prominent screened porch runs the entire length of the front (east side) of the structure, bounded by columns that support the roof.

Her father, Joseph LaFlesche, was the tribe's last recognized chief, and saw to it that his children were well educated and could integrate into white society.

[5] In 2017, Judi M. gaiashkibos, executive director of the Nebraska Commission on Indian Affairs, set up a committee of Picotte's descendants and community leaders from the Omaha tribe, to help plan the restoration of hospital.

Using funding raised from the United States Department of Agriculture and private donations, the hospital was renovated and redesigned to house a medical clinic, museum, and cultural center.