The Susan La Flesche Picotte House is a wood-frame house in Walthill, Nebraska built in 1907 that was a home of Dr. Susan La Flesche Picotte, the first Native American medical doctor and a political advocate for the rights of the Omaha people.

[1] It is a two-and-a-half-story wood-frame house with simple detailing on a concrete block foundation.

It looks distinctive relative to simpler gable roof houses, as it has a jerkinhead which clips off the pointy end of the gable, and it has returning eaves, thus making a trapezoidal shape on the front facade above the second floor windows.

As of 2009, the house had its original clapboard siding and had recently been painted green with white and maroon trim, compatible with its appearance when Susan La Flesche Picotte lived there.

The Dr. Susan Picotte Memorial Hospital, also in Walthill, was built in 1912–13 to serve as a facility for her practice.