Initially drafted as a nickel back who could fill in at safety if needed, Florence had fought his way to become a legitimate starting cornerback in the NFL across Quentin Jammer.

On Sunday, January 14, 2007, in the AFC Divisional Playoff game against the New England Patriots after a muffed punt by wide receiver Eric Parker at the San Diego 31-yard line, Florence committed a personal foul, head-butting Patriot TE Daniel Graham following a 3rd and long play.

[4] The NFL fined Florence $15,000 for the illegal hit he put on Houston Texans Quarterback Matt Schaub on Sunday October 28.

On an interception return, he drilled Schaub from the blind side, and was penalized 15 yards for unnecessary roughness.

The league ruled that on a change of possession, Florence unnecessarily made helmet-to-helmet contact with Schaub, who suffered a concussion and missed the rest of the game.

Florence made the starting rotation under Head Coach Dick Jauron[7][circular reference].

On May 1, 2015, he retired from the NFL and graduated from the University of North Florida with a bachelor's degree in Sports Management.