The label operates across a range of genres, from dancehall to underground club music, experimental electronic, rap and leftfield pop.

The label's early years saw releases spanning dancehall, synth pop, UK funky house, punk, and more.

[2] In 2011, following a trip to Jamaica, Mixpak released its first full-length album: Kingston Story by Vybz Kartel, featuring the singles “Yuh Love”, “Go Go Wine”, and “Half on a Baby”.

[8] In 2016, Mixpak won Red Bull Culture Clash in London, defeating Wiz Khalifa, UKG Allstars and Wiley's Eskimo Dance for the trophy.

[14] As well as releasing records, Mixpak throws a series of parties in New York City and hosts a monthly show on Red Bull Radio.