Other notable roles include Gina Tribbiani on Joey (2004–2006), Wendy Case on Sons of Anarchy (2008–2014), Angie Bolen on Desperate Housewives (2009–2010), and Detective Tess Nazario on Shades of Blue (2016–2018).

Her mother Donna is a playwright and playwriting teacher who has been on faculty at HB Studio,[2] and her father, Albert, was a furniture manufacturer who was owner and CEO of Avery Boardman and Carlyle.

The pilot episode aired September 3, 2008, and De Matteo continued making regular appearances into the series' sixth season.

[24] In 1997, De Matteo opened Filth Mart, a clothing store with her boyfriend Michael Sportes.

[27] They became engaged on June 11, 2009, when Jennings proposed onstage at the Stanley Theater during a show in Utica, New York.

[31] De Matteo lost her apartment home of 22 years when a gas explosion and fire destroyed three buildings in Manhattan on March 26, 2015.

[32] In July 2024, De Matteo revealed on a podcast that her 13-year-old son edits her content posted on the platform OnlyFans.