She gained wider recognition with her performances in Baz Luhrmann's The Great Gatsby (2013)—which won her the AACTA Award for Best Supporting Actress—and as Ayesha in the Marvel films Guardians of the Galaxy Vol.

Debicki's profile grew with roles in the limited series The Kettering Incident and The Night Manager (both 2016) and in Steve McQueen's heist thriller Widows (2018), and in 2019, she received the Cannes Trophée Chopard.

Debicki gained international recognition and received various accolades such as the Golden Globe and Primetime Emmy Award for Outstanding Supporting Actress in a Drama Series as Diana, Princess of Wales in The Crown (2022–2023).

She played the lead role of Dr. Anna Macy in the eight-part Australian television series The Kettering Incident, which was largely shot on location in Tasmania.

[30] Following the success of The Night Manager, Debicki landed a supporting role in the Marvel Studios film Guardians of the Galaxy Vol.

[31] In June 2017, she was added to the cast of director Luc Besson's Valerian and the City of a Thousand Planets in an undisclosed voice-over role.

2017 also saw Debicki as Eva in Australian actor Simon Baker's directorial debut Breath, for which she would receive an AACTA Award nomination for Best Actress in a Supporting Role.

[36] Upon the film's release, she received some of the best reviews of her career, with many critics stating how impressed they were that she managed to stand out among such a crowded cast, which included the likes of Viola Davis and Liam Neeson.

Debicki had a leading role in the 2019 thriller The Burnt Orange Heresy, in which she starred opposite Claes Bang and Mick Jagger.

[38] The following year, she starred in Christopher Nolan's spy film Tenet (2020)[39] as Kat, the estranged wife of Kenneth Branagh's character.

Peter Bradshaw of The Guardian thought that she had "the most recognisable human emotions here, shouting, crying and even smiling in a way that no one else quite does" but added that her role was similar to the one she played in The Night Manager.

[40] In an interview with The Hindu, Debicki recalls, "Playing Kat, I understood the harrowing scenes are important to show the audience the threats to her existence — physical and psychological — she faced.