The singleplayer campaign is made up of eleven levels in which the player takes the role of Judge Dredd and battles a series of criminals and undead vampires.

Attacking Judges, civilians, and criminals that have surrendered will also deplete the law meter, with a more severe penalty if they are killed.

If the law meter is fully depleted the current level will become unwinnable, and the Special Judicial Squad will arrive to execute the player.

After dispatching them, Dredd is informed that an aircraft filled with vampires has crashed into the Nixon penitentiary, disabling all of the automated defenses and sparking a prison riot.

Without any leads to follow up on, Dredd returns to regular patrol while the Psi Division tries to locate the Dark Judges.

Dredd stumbles upon a death cult that is in the process of creating physical bodies for the Dark Judges' spirits to inhabit.

By the time Dredd manages to fight through the cult, the ritual has already been completed and the Dark Judges are once again roaming the streets of Mega-City One.

Though it is initially believed that the outbreak is the work of Judge Death, it is later determined that both the vampires and zombies that have been appearing in Mega-City One are humans infected by a genetically engineered retrovirus developed by Dr. Icarus for a pet reanimation business.

Dredd makes his way through the hospital and helps the patients get to safety before corralling Judge Mortis into a quarantine chamber with disinfectant.

Gordon Rennie wrote a Dredd vs. Death novelization, published by Black Flame, as a tie-in to the game (October 2003, ISBN 1-84416-061-0).

[6] On January 27, 2004, Rebellion announced that Evolved Games purchased the North American publishing rights to the title, and would release it in March 2004.

The arcade mode was also noted as being superior compared to the campaign (IGN said it "adds some spice to an otherwise boiled and blanched game"[18]).

IGN concluded, "Fans of the fiction will finally appreciate a style that keeps its faith, but will wonder how this game could have done its source material the same sort of disservice the decade old movie did",[18] negatively comparing it to the 1995 film Judge Dredd.