The remarkable name Drei Annen ("Three Annes") was first mentioned in 1770, when the lord of the manor, Count Christian Frederick of Stolberg-Wernigerode sanctioned the mining of copper and silver at the place, reserving mine shares for himself and his mother Princess Christiane Anna of Anhalt-Köthen, his newborn daughter Anne, and his neonate niece Anna Emilia, daughter of his brother–in–law Prince Frederick Erdmann of Anhalt-Pless.
When in 1871 Count Otto of Stolberg-Wernigerode had the road to Schierke rebuilt as a highway (the present-day Hagenstraße), the inn was enlarged as a toll station.
When on 20 June 1898 the first section of the Harz Railway from Wernigerode opened, the tracks ran right beside the Drei Annen highway inn, but the new station was established on a plateau about 1 km (600 ft) to the southwest near the comital forester's lodge at the Hohne rocks.
From the 1950s the Drei Annen inn was run as a recreation home by the East German mechanical engineering combine at Magdeburg, it is today again a restaurant and a hotel.
The mighty oak trunk has traces of fire on one side that it received at the end of the Second World War when a Tiger tank under the tree was blown up.