In June 2008, Lachey joined the Broadway company of Monty Python's Spamalot as Patsy, the faithful manservant to King Arthur and stayed with the show for three months.

At the beginning of the sixth week of competition (aired in February 2006), Lachey and Burke earned a perfect score of 30 with their tango.

On the April 17, 2007, results show, Lachey made a surprise appearance to reprise his "Save a Horse (Ride a Cowboy)" freestyle dance with Cheryl Burke.

He co-hosted the first 3 weeks of the fifth season of Dancing with the Stars, temporarily replacing Samantha Harris during her maternity leave.

When Gloria Estefan had to pull out of the October 16, 2007, results show for personal reasons, Lachey returned to dance a foxtrot with Cheryl.

Drew and design partner Sabrina Soto won the celebrity edition of HGTV's Showdown, "Battle of the Bonus Room" shown in July, 2009.

In May 2019, Lachey competed in the eleventh season of American Ninja Warrior, where he was eliminated in the second obstacle in the Cincinnati city course.