"[7] After graduating from college, Struzan remained in Los Angeles, and a trip to an employment agency found him a job as a staff artist for Pacific Eye & Ear, a design studio.

There he began designing album covers under the direction of Ernie Cefalu, relishing the creative aspects the 12x12" size the record packaging afforded him.

Over the next 5 years, he would create album cover artwork for a long line of musical artists, including Tony Orlando and Dawn, The Beach Boys, Bee Gees, Roy Orbison, Black Sabbath, Glenn Miller, Iron Butterfly, Bach, Earth, Wind & Fire, and Liberace.

His first film poster works started appearing in 1975, although in those early days Struzan mainly did artwork for B-movies, such as Empire of the Ants, Food of the Gods, and Squirm.

In 1977 fellow artist Charles White III, well known for his own airbrush prowess, had been hired by David Weitzner, Vice President of advertising at 20th Century Fox, to create a poster design for the 1978 re-release of Star Wars.

the Extra-Terrestrial, The Muppet Movie, Coming to America, First Blood, Risky Business, D.C. Cab, Stroker Ace, Batteries Not Included, An American Tail, and The Goonies.

While continuing to create artwork for such 1990s and 2000s films as Hook, Hellboy and the American poster for Harry Potter and the Philosopher's Stone, he started exploring other outlets for his work, including comic books, limited-edition art, and the collectible market.

[15][16] Struzan once lamented on the decline of traditional art in an e-mail exchange: I love the texture of paint made of colored earth, of oil from the trees and of canvas and paper.

In 1999, in an exhibit entitled Drew: Art of the Cinema, Struzan had over 65 pieces of his artwork presented at the Norman Rockwell Museum in Stockbridge, Massachusetts.

[18] For the release of Star Wars: Episode I – The Phantom Menace, George Lucas dictated that, contractually, Struzan's poster was the only art the foreign distributors could use, and other than the text, it could not be modified in any way.

[20] After completing the extensive artwork required for the campaign of Indiana Jones and the Kingdom of the Crystal Skull, Struzan announced his retirement on September 3, 2008.

[21] In 2009, Struzan (in collaboration with Jim Sanders of Reel Ideas) produced a DVD, Conceiving and Creating the Hellboy Movie Poster Art, as a step-by-step documentation of his creative process, techniques, and industrial experience.

[22] In September 2009, Struzan produced an image for publication in Kurv magazine of Mattel's Barbie, in celebration of that doll's 50th anniversary year.

The performance included composers Thomas Newman, John Debney, Brian Tyler, Marco Beltrami, Robert Folk, and Michael Kosarin, as guest conductors.

With the theatrical release of the Star Wars special editions, Struzan created the three-panel triptych within the limited four-week deadline.