The Drexel Mission Fight was an armed confrontation between Lakota warriors and the United States Army that took place on the Pine Ridge Indian Reservation in South Dakota on December 30, 1890, the day after the Wounded Knee Massacre.

The fight occurred on White Clay Creek approximately 15 miles (24 km) north of Pine Ridge where Lakota were purported to have burned the Catholic Mission.

These Indians were purported to be the same Brulé Lakota under Chief Two Strike that had attacked the 9th Cavalry's supply train earlier that morning.

Secretary of War Redfield Proctor set aside the Drexel Mission investigation after exonerating Forsyth of any wrongdoing at Wounded Knee.

[2] Three soldiers were awarded the Medal of Honor for actions at White Clay Creek, including Captain Charles A. Varnum, First Sergeant Theodore Ragnar, and Farrier Richard J. Nolan.