Since January 2001, multiple drone strikes have been conducted by the United States government in Afghanistan.

These strikes began during the administration of the United States President George W. Bush.

[8] By 2021, there had been a total of at least 13,074 airstrikes conducted by the US government, killing at least 4,138 people, including 310 civilians and 73 children.

[9] The civilian casualties faced criticism and many killed being unintended targets.

[62][63][64] Amnesty International USA has also questioned the legality of drone attacks.