The original version of the song did not feature Chris Brown, and maintained the same lyrics on the second verse but coming from a man's perspective.

Pop singer Britney Spears wanted to record "Drop It Low" for her album Femme Fatale before Dean used it as her own single.

[6] After that, the official remix was released with Diddy talking throughout the track, replacing Trey Songz on the intro, and with a slight change in beat during Chris Brown's verse.

The video features both Dean and Brown, as well as some cameo appearances by Nelly, Keri Hilson, Teyana Taylor, Polow da Don, Omarion, Audio Push, Twerk Team, Soulja Boy, Rich Boy, Brandy, and Barry "Mijo" Bradford.

[15] The song's tempo and rhythms were recycled for the track "Work Wit It" by Chris Brown on his mixtape In My Zone.