There is an overarching plot but no clear single arc except that of the life-cycle of a neighbourhood, its deterioration and renewal.
In the form of chronicles, most tales only last few pages, however there are multiple core characters whose stories are spread throughout.
The chronicles tell about life, problems, and solutions about inter-ethnic and other socioeconomic relations of residents of Dropsie Avenue in New York City.
Kitchen Sink Press published the book in 1995 as the third volume of the Contract with God trilogy.
W. W. Norton then acquired Eisner's catalogue and released A Contract with God, A Life Force, and Dropsie Avenue in a single-volume edition in 2006, and in 2007 released the three books in standalone editions.