Drosophila falleni is a species of fly found in northeastern North America.
[1] A mycophagous insect, it is known to feed on the fruit bodies (mushrooms) of several genera of fungi, including Agaricus, Amanita, Agrocybe, Boletus, Cortinarius, Pluteus Grifola, Polyporus, Hypholoma, Russula, Mycena, Stropharia, and Xerula.
[2] The fly can be infested by the parasitic nematode Howardula aoronymphium, which enters the fly larvae when it is feeding on mushrooms.
Infection by H. aoronymphium alters D. falleni olfactory preferences, causing infected flies to become more averse to acetate-containing compounds such as ethyl acetate or propyl acetate.
[4] The genome of D. falleni was sequenced in 2019 as part of a study on the evolution of immune systems.