In the southern part of Leidy Township, it picks up the tributaries Sandy Run and Woodley Draft and the stream bends southeast.
It picks up the tributary Stony Run before entering the West Branch Susquehanna River on the western edge of Renovo.
[3] At the mouth of Stony Run, the concentration of aluminum in the water is 7.11 milligrams per liter and there is a daily load of 96.65 pounds (43.84 kg).
The iron concentration is 0.29 milligrams per liter and the load of this metal is 3.94 pounds (1.79 kg) per day.
[3] The total daily load of acid mine drainage in the watershed is 658 pounds (298 kg) per day.
[5] Drury Run experiences acid mine drainage, mostly in the final 3.5 miles (5.6 km).
[3] The watershed is underlain by Pennsylvanian age sedimentary rocks of the Pottsville and Allegheny Formations.
Underground mining of coal and clay in the Drury Run watershed began in the late 1800s and went on until 1940.
[3] Drury Run is a high-quality trout stream from its source at Tamarack Swamp to the mouth of Woodley Draft.
Downstream of Woodley Draft, it still supports fish, but is also impaired by acid mine drainage.
[5] Upstream from acid mine inflows, Drury Creek and its tributaries have healthy macroinvertebrate communities.
They exhibit high species diversity, with mayflies (an acid-intolerant group) making up more than 40 percent of the macroinvertebrate population.