When Darius III began a military campaign against the invading army of Alexander the Great, he was accompanied by Drypetis, along with her sister, her mother, and her grandmother Sisygambis.
[1] Although Darius tried repeatedly to ransom his family, Alexander kept them with him until 331 BCE when Drypetis and her sister were sent to Susa to learn the Greek language.
[1][2][3] Soon after, Drypetis was widowed when Hephaestion accompanied Alexander to Ecbatana and upon arriving in autumn, died after falling ill with a severe fever.
[4] Many historians accept Plutarch's account that Drypetis was killed in 323 BCE alongside her sister Stateira.
[2][5] Instead, Carney theorizes that Roxana killed Parysatis II (daughter of Artaxerxes III of Persia), who was also a wife of Alexander.