Duane Denison (born January 21, 1959) is an American guitarist best known for work with the punk rock band The Jesus Lizard.

"Denison has played warped jazz-rock with Firewater, cool jazz with the Denison-Kimball Trio, experimental alt-metal with Tomahawk, rockabilly punk with Th’ Legendary Shack Shakers, and outlaw country with Hank Williams III.

Tightly controlled yet capable of ripping and tearing like a runaway chainsaw, Denison’s riffs influenced an entire generation of post-hardcore guitarists, including the burgeoning wave of noise-punkers like the Men and Roomrunner.” [2] In 1999 Denison moved to Nashville after The Jesus Lizard broke up in order to play with Hank Williams III's "Damn Band".

[3] Soon after his move to Nashville, Denison began collaborating and exchanging demo tapes with Mike Patton, whom he met at a Mr. Bungle show in 1999.

[citation needed] Duane Denison's playing has influenced several notable guitarists, including Limp Bizkit's Wes Borland, Jimmy Eat World's Jim Adkins, and Every Time I Die's Andy Williams.