1067, "Mr. Duane entered in March, 1765 into contract with a company of twenty Germans from Pennsylvania of whom about sixteen (families) came on tract, and they made the first permanent settlement in that now flourishing town".

[10][11][12][13] The village of Delanson within the town of Duanesburg was an important stop for the Delaware and Hudson Railroad.

In the flat-bottomed valley east of the village of Delanson were huge coal storage piles over 100 feet (30 m) high.

Many densely packed wooden shops lined the village street on the north and south sides of the tracks.

In the late 20th century farming fell into decline, and the town became a home for commuters working in Albany and Schenectady.

General Electric provided a stable and lucrative income for many non-agricultural residents who built homes in the town during this time.

Despite this, the town government has support the birth and growth of the first Winery in Duanesburg, Helderberg Meadworks, which began selling their mead in October 2012 through local wine stores and as of June 2014 has expanded to statewide distribution.

During the late 1990s Harrison Ford used to be a repeat visitor at the restaurant during rest stops at the local airport while en route to other destinations.

The town continues to provide an extensive network of ATV trails through picturesque woods and rural land, most of which is private.

[16] The town consists of mostly wooded hills up to an elevation of approximately 1,400 feet (430 m) above sea level.

After this point forests grew to cover 60% of the total land area with a canopy higher than 40 feet (12 m).

The forest is primary composed of poplar, hemlock, oak, maple, white pine, and balsam fir.

These creeks drop over a series of rapids and waterfalls cut through shale and sandstone rock beds.

Most of the soil contains clay, significant loose rock, and/or shallow depth, therefore making it inadequate for a large farming industry.

There is a significant amount of swamps at high and low elevations in the town due to clay soil and past glacial activity.

The rest of the south and part of the west town line is the border of Schoharie County.