For comparison, the Dubois ZIP Code is 324 square miles (840 km2) larger than the entire state of Rhode Island.

[7] In protest, the citizens of Dubois rejected the French pronunciation of "deh-bwah", instead opting for Du, with u as in "Sue"; bois, with oi as in "voice".

[9] The Wind River Valley surrounding Dubois contains numerous remnants of these people who lived in the area for many hundreds of years before they were relocated into a nearby reservation.

[9][10] Relics of their existence in the mountains and valleys around Dubois include numerous prehistoric petroglyphs, hunting traps and blinds, and stone tepee circles.

[11] In the years to follow, the Wind River valley was visited regularly by the Astorians and other fur trappers and hunters through the early 19th century.

[11] Butch Cassidy (Robert LeRoy Parker) owned and managed a ranch on the outskirts of Dubois, beginning in 1890.

In 1913, the town expanded with the addition of a hotel, a bar, and a general store, anticipating the arrival of Scandinavian lumber workers brought there by the Wyoming Tie and Timber Company the following year.

These Scandinavian immigrants cut logs into ties and sent these via the flumes to the Wind River where they floated to Riverton, about 70 miles east, for processing.

[14] The Dubois Museum preserves and interprets the natural and social history of the Upper Wind River Valley[15] as the National Bighorn Sheep Interpretive Center focuses on public education about the biology and habitat of the Rocky Mountain Bighorn Sheep with focus on the largest herd of Rocky Mountain Bighorn sheep in the coterminous United States that winter in the Whiskey Basin of Whiskey Mountain adjacent to the Fitzpatrick Wilderness[16] in the Shoshone National Forest.

A significant proportion of Dubois residents are writers, artists, photographers, musicians and songwriters, drawn to the remote town in part by its relatively moderate climate and remarkable scenery.

During summer months, a square dance and a rodeo including local and regional competitors take place every week.

The origin of the fire appeared to be inside the rear of the "Main Street Mart" building in the attic above a wood stove.

The fire was most likely caused by charring (pyrolysis) that resulted from the chimney coming into contact with building materials.

The privately funded $100M museum was founded by Dan Starks, a former lawyer and CEO of St. Jude Medical.

Public education in the town of Dubois is provided by Fremont County School District #2.

[25] The geology of the area surrounding Dubois is unique in the world for featuring (almost in the same view) examples of all three major mountain-building forces: tectonic, volcanic, and glacial.

The body of Marine PFC Chance Phelps was taken to his parents' home in Dubois after his death in Iraq in 2004.