Lysite (also Lysaght) is an unincorporated community in northeastern Fremont County, Wyoming, United States.

[3] The Bridger Trail passed near Lysite on its way north to the gold fields of Montana in the 19th century.

During a drought in 1960, Lysite recorded 1.28 inches or 32.5 millimetres of precipitation for the entire calendar year.

Every summer the community hosts a series of mini rodeos called the gymkhanas.

[citation needed] Public education in the community of Lysite is provided by Fremont County School District #24.